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Watch the video below to learn more about what happens in the body of someone with Alpha‑1 antitrypsin deficiency (Alpha‑1, for short).

Take a closer look at Alpha‑1

Video thumbnail showing lung damage caused by alpha‑1 antitrypsin deficiency.

Alpha‑1 can result in serious lung disease in adults. It also may result in liver disease at any age. Whether Alpha‑1 may affect the lungs, the liver, or both depends on the combination of Alpha‑1 genes someone has and other risk factors. The Alpha‑1 Basics page has more details about Alpha‑1 genetics and what symptoms may be associated with this rare disorder.

Alpha‑1 is a genetic condition that can damage the lungs—

Learn more about
Alpha‑1 Antitrypsin Deficiency

but there’s a test your doctor can do to see if you’re at risk.

Find out about Alpha‑1 testing
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Up to 30% of people with COPD (chronic obstructive pulmonary disease) or asthma may have an underlying genetic cause, such as Alpha‑1, for their lung disease.

Discover more about Alpha‑1

Husband and wife talking about management options for Alpha-1.

If you have Alpha‑1, be sure to talk to your doctor about this condition and options to help manage it.

Explore Alpha‑1 management

Explore helpful resources and get tips for living with Alpha‑1.

Get support for Alpha‑1
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